diff --git a/.config/setup/04-install-deb-packages.sh b/.config/setup/04-install-deb-packages.sh
index ae5a17e..a8d976f 100755
--- a/.config/setup/04-install-deb-packages.sh
+++ b/.config/setup/04-install-deb-packages.sh
@@ -60,7 +60,6 @@ DEB_PKGS=(
     ntfs-3g
     nvtop
     pipewire-audio
-    pipx
     postfix
     pre-commit
     pulseaudio-utils
diff --git a/.config/setup/06-install-pipx-packages.sh b/.config/setup/06-install-pipx-packages.sh
deleted file mode 100755
index e7bc1eb..0000000
--- a/.config/setup/06-install-pipx-packages.sh
+++ /dev/null
@@ -1,32 +0,0 @@
-#! /usr/bin/bash
-
-set -euo pipefail
-IFS=$'\n\t'
-
-PIPX_PKGS=(
-    # keep-sorted start
-    python-lsp-server
-    rshell
-    ruff
-    # keep-sorted end
-)
-
-if (( "${#PIPX_PKGS[@]}" != 0 )); then
-    pipx install "${PIPX_PKGS[@]}"
-fi
-
-PYLSP_PLUGINS=(
-    # keep-sorted start
-    fs
-    podman
-    pydantic
-    pylsp-mypy
-    pylsp-rope
-    pytest
-    testcontainers
-    types-docker
-    types-pyxdg
-    # keep-sorted end
-)
-
-pipx inject python-lsp-server "${PYLSP_PLUGINS[@]}"
diff --git a/.config/setup/46-install-uv-packages.sh b/.config/setup/46-install-uv-packages.sh
new file mode 100755
index 0000000..0c09810
--- /dev/null
+++ b/.config/setup/46-install-uv-packages.sh
@@ -0,0 +1,30 @@
+#! /usr/bin/bash
+
+set -euo pipefail
+IFS=$'\n\t'
+
+UV_PKGS=(
+    # keep-sorted start
+    rshell
+    ruff
+    # keep-sorted end
+)
+
+for package in "${UV_PKGS[@]}"; do
+    uv tool install "${package}"
+done
+
+PYLSP_PLUGINS=(
+    # keep-sorted start
+    --with fs
+    --with podman
+    --with pydantic
+    --with pylsp-mypy
+    --with pylsp-rope
+    --with pytest
+    --with testcontainers
+    --with types-docker
+    --with types-pyxdg
+    # keep-sorted end
+)
+uv tool install "${PYLSP_PLUGINS[@]}" python-lsp-server
diff --git a/.local/bin/upgrade b/.local/bin/upgrade
index 3e85388..9e432c7 100755
--- a/.local/bin/upgrade
+++ b/.local/bin/upgrade
@@ -19,8 +19,8 @@ cargo_update() {
     cargo install $(cargo install --list | grep '^[a-z0-9_-]\+ v[0-9.]\+:$' | cut --delimiter=' ' --fields=1)
 }
 
-pipx_update() {
-    pipx upgrade-all
+uv_update() {
+    uv tool upgrade --all
 }
 
 git_sync_update() {
@@ -38,7 +38,7 @@ podman_update() {
 
 apt_update
 emacs_update
-pipx_update
+uv_update
 cargo_update
 ghup
 git_sync_update